Nizatidine

Nizatidine

SCHEMBL769

CN/C(=C\[N+](=O)[O-])NCCSCc1csc(CN(C)C)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH2

The experimentally established mechanism targets of Nizatidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 known ✓ P25021 2/20 0.59
ACHE P22303 7/20 1.00
MEN1 O00255 1/20 0.59
SLC22A1 O15245 1/20 0.59
ABCB11 O95342 1/20 0.59
LMNA P02545 1/20 0.59
CHRM2 P08172 1/20 0.59
CHRM1 P11229 1/20 0.59
TSHR P16473 1/20 0.59
ADRA2C P18825 1/20 0.59
NFKB1 P19838 1/20 0.59
CHRM3 P20309 1/20 0.59
ATP4A P20648 1/20 0.59
PTGS1 P23219 1/20 0.59
SLC6A4 P31645 1/20 0.59
CYP2C19 P33261 1/20 0.59
ADRA1A P35348 1/20 0.59
PTGS2 P35354 1/20 0.59
ATP4B P51164 1/20 0.59
KMT2A Q03164 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nizatidine SCHEMBL13575816 1.00 ACHE (1.00) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL770 1.00 ACHE (1.00) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL9241933 1.00 ACHE (1.00) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL28723397 0.99 ACHE (0.98) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL5041217 0.99 ACHE (0.98) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL6239553 0.98 ACHE (0.96) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL28102651 0.97 ACHE (0.94) ACHEHRH2MEN1SLC22A1ABCB11
SCHEMBL10425830 0.95 ACHE (0.91) ACHEHRH2MEN1SLC22A1ABCB11
SCHEMBL4344477 0.95 ACHE (0.90) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL158261 0.94 ACHE (0.88) ACHEHRH2MEN1SLC22A1ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 16623 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122082051-A Aluminum-silicon alloy and preparation method thereof 2026-05-26 CN claimed
CN-117363911-B Melt composite treatment method capable of improving mechanical and heat conducting properties of cast aluminum alloy 广东省科学院新材料研究所 2026-05-15 CN claimed
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
WO-2026090593-A2 RNA BIOMARKERS FOR USE IN BARRETT'S ESOPHAGUS CITY OF HOPE (US) 2026-04-30 WO claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
US-20260069593-A1 METHODS FOR TREATING CANCER AMGEN INC (US) 2026-03-12 US claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
US-12544376-B2 Amorphous solid dispersions of dasatinib and uses thereof HANDA THERAPEUTICS, LLC (US) 2026-02-10 US claimed
US-12496295-B2 Veterinary pharmaceutical compositions for direct systemic introduction NEWMARKET PHARMACEUTICALS LLC (US) 2025-12-16 US claimed
US-20250367126-A1 SOFTGEL CAPSULE COMPRISING A H2 RECEPTOR ANTAGONIST KENVUE BRANDS LLC (US) 2025-12-04 US claimed
US-4638157-A Detecting apparatus utilizing light beams KUBOTA, LTD. (JP) 1987-01-20 US claimed
US-4607548-A Pliers MILBAR CORPORATION (US) 1986-08-26 US claimed
EP-0179143-A1 METHOD AND APPARATUS FOR PRODUCING A CONTROLLED PRELOAD ON A TRANSDUCER ASSEMBLY BY MEANS OF A COMPOSITE MATERIAL SLEEVE. SUNDSTRAND DATA CONTROL (US) 1986-04-30 EP claimed
WO-1985005058-A1 METHOD AN APPARATUS FOR PRODUCING A CONTROLLED PRELOAD ON A TRANSDUCER ASSEMBLY BY MEANS OF A COMPOSITE MATERIAL SLEEVE SUNDSTRAND DATA CONTROL, INC. (US) 1985-11-21 WO claimed
EP-0116452-A2 Improvements in or relating to the synthesis of nizatidine ELI LILLY AND COMPANY (US) 1984-08-22 EP claimed
EP-0043493-B1 DEVICE FOR THE DEVELOPMENT OF PHOTOGRAPHIC MATERIAL JOBO Labortechnik GmbH & Co. KG (DE) 1984-06-06 EP claimed
EP-0007339-B1 APPARATUS FOR PANORAMIC RADIOGRAPHY THOMSON-CSF (FR) 1982-05-19 EP claimed
US-4270394-A Toning shaft for a rotary switch MURATA MANUFACTURING CO., LTD. (JP) 1981-06-02 US claimed
EP-0010323-A1 A method for producing orthogonally screened colour separation images STORK BRABANT B.V. (NL) 1980-04-30 EP claimed
US-4132332-A Containers for pressurized fluids, in particular for dispensing aerosols WASSILIEFF VICTOR 1979-01-02 US claimed