Nizatidine

Nizatidine

SCHEMBL158261

CN/C(=C\[N+](=O)[O-])NCCSCc1csc(CN(C)C)n1.NCC(=O)O

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH2

The experimentally established mechanism targets of Nizatidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 known ✓ P25021 2/20 0.53
ACHE P22303 4/20 0.88
MEN1 O00255 1/20 0.53
SLC22A1 O15245 1/20 0.53
ABCB11 O95342 1/20 0.53
LMNA P02545 1/20 0.53
CHRM2 P08172 1/20 0.53
CHRM1 P11229 1/20 0.53
TSHR P16473 1/20 0.53
ADRA2C P18825 1/20 0.53
NFKB1 P19838 1/20 0.53
CHRM3 P20309 1/20 0.53
ATP4A P20648 1/20 0.53
PTGS1 P23219 1/20 0.53
SLC6A4 P31645 1/20 0.53
CYP2C19 P33261 1/20 0.53
ADRA1A P35348 1/20 0.53
PTGS2 P35354 1/20 0.53
ATP4B P51164 1/20 0.53
KMT2A Q03164 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nizatidine SCHEMBL769 0.94 ACHE (1.00) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL770 0.94 ACHE (1.00) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL13575816 0.94 ACHE (1.00) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL9241933 0.94 ACHE (1.00) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL28723397 0.93 ACHE (0.98) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL5041217 0.93 ACHE (0.98) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL6239553 0.92 ACHE (0.96) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL28102651 0.91 ACHE (0.94) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL9369533 0.89 ACHE (0.80) ACHEHRH2MEN1SLC22A1ABCB11
Nizatidine SCHEMBL9369530 0.89 ACHE (0.80) ACHEHRH2MEN1SLC22A1ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10227598-B2 Sugarcane bacilliform viral (SCBV) enhancer and its use in plant functional genomics DOW AGROSCIENCES LLC (US) 2019-03-12 US disclosed
EP-3362071-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY Grünenthal GmbH (DE) 2018-08-22 EP disclosed
EP-2611925-B1 SUGARCANE BACILLIFORM VIRAL (SCBV) ENHANCER AND ITS USE IN PLANT FUNCTIONAL GENOMICS DOW AGROSCIENCES LLC (US) 2017-11-29 EP disclosed
WO-2017049294-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY THAR PHARMACEUTICALS, INC. (US) 2017-03-23 WO disclosed
US-20160251733-A1 SUGARCANE BACILLIFORM VIRAL (SCBV) ENHANCER AND ITS USE IN PLANT FUNCTIONAL GENOMICS DOW AGROSCIENCES LLC (US) 2016-09-01 US disclosed
CN-103201389-B Sugarcane bacilliform virus (SCBV) enhanser and the purposes in plant functional genomics thereof DOW AGROSCIENCES LLC (US) 2015-09-23 CN disclosed
US-20140289899-A1 SUGARCANE BACILLIFORM VIRAL (SCBV) ENHANCER AND ITS USE IN PLANT FUNCTIONAL GENOMICS DOW AGROSCIENCES LLC 2014-09-25 US disclosed
US-8785612-B2 Sugarcane bacilliform viral (SCBV) enhancer and its use in plant functional genomics AGRIGENETICS, INC. (US) 2014-07-22 US disclosed
EP-2611925-A1 SUGARCANE BACILLIFORM VIRAL (SCBV) ENHANCER AND ITS USE IN PLANT FUNCTIONAL GENOMICS Dow AgroSciences LLC (US) 2013-07-10 EP disclosed
CN-103201389-A Sugarcane bacilliform viral (SCBV) enhancer and its use in plant functional genomics DOW AGROSCIENCES LLC 2013-07-10 CN disclosed
WO-2011097269-A9 CRYSTALLIZATION METHOD AND BIOAVAILABILITY THAR PHARMACEUTICALS, INC. (US) 2012-12-27 WO disclosed
EP-2531200-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY Thar Pharmaceuticals, Inc. (US) 2012-12-12 EP disclosed
WO-2012030711-A1 SUGARCANE BACILLIFORM VIRAL (SCBV) ENHANCER AND ITS USE IN PLANT FUNCTIONAL GENOMICS AGRIGENETICS, INC. (US) 2012-03-08 WO disclosed
US-20120054908-A1 SUGARCANE BACILLIFORM VIRAL (SCBV) ENHANCER AND ITS USE IN PLANT FUNCTIONAL GENOMICS AGRIGENETICS, INC. 2012-03-01 US disclosed
WO-2011097269-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY THAR PHARMACEUTICALS, INC. (US) 2011-08-11 WO disclosed
US-7667100-B2 Nucleic acid compositions conferring herbicide resistance DOW AGROSCIENCES LLC (US) 2010-02-23 US disclosed
US-20050066392-A1 Nucleic acid compositions conferring herbicide resistance DOW AGROSCIENCES LLC 2005-03-24 US disclosed