Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.41 |
| ▸ | F10 | P00742 | 12/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451721 | 1.00 | F2 (0.41) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7451638 | 0.80 | F10 (0.59) | F2PRSS1F10KCNH2 | |
| SCHEMBL7688216 | 0.80 | F10 (0.59) | F2PRSS1F10KCNH2 | |
| SCHEMBL7690248 | 0.79 | ADAMTS4 (0.39) | — | |
| SCHEMBL7451725 | 0.79 | ADAMTS4 (0.39) | — | |
| SCHEMBL7368049 | 0.78 | F2 (0.59) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7447865 | 0.77 | F10 (0.63) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7688608 | 0.77 | F10 (0.63) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7459605 | 0.77 | F2 (0.59) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7454491 | 0.75 | F2 (0.43) | F2PRSS1PRSS2PRSS3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399627-B1 | ANTICOAGULANTS; PROTHROMINASE, SERINE PROTEASE INHIBITOR; ACRYLAMIDE DERIVATIVES | COR THERAPEUTICS, INC. | 2002-06-04 | — | — | US | disclosed |
| EP-1159264-A2 | INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047554-A2 | INHIBITORS OF FACTOR Xa | COR THERAPEUTICS INC. (US) | 2000-08-17 | — | — | WO | disclosed |