Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 18/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094515 | 0.94 | SIGMAR1 (0.53) | TBXAS1TBXA2R | |
| SCHEMBL11229130 | 0.93 | TBXAS1 (0.54) | TBXAS1 | |
| SCHEMBL8418666 | 0.93 | TBXAS1 (0.54) | TBXAS1 | |
| SCHEMBL11792681 | 0.93 | TBXAS1 (0.54) | TBXAS1 | |
| SCHEMBL9169660 | 0.93 | TBXAS1 (0.54) | TBXAS1 | |
| SCHEMBL7861116 | 0.93 | TBXAS1 (0.54) | TBXAS1 | |
| SCHEMBL726651 | 0.91 | TBXAS1 (0.53) | TBXAS1 | |
| SCHEMBL3803676 | 0.91 | TBXAS1 (0.53) | TBXAS1 | |
| SCHEMBL8647922 | 0.91 | TBXAS1 (0.53) | TBXAS1 | |
| SCHEMBL8710360 | 0.91 | TBXAS1 (0.53) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017684-B1 | CONTRASTING AGENT FOR INFARCT AND NECROSIS IMAGING | SCHERING AG (DE) | 2002-11-20 | — | — | EP | disclosed |
| EP-1017684-A1 | CONTRASTING AGENT FOR INFARCT AND NECROSIS IMAGING | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999016757-A1 | CONTRASTING AGENT FOR INFARCT AND NECROSIS IMAGING | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-04-08 | — | — | WO | disclosed |