Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 3/20 | 0.48 |
| ▸ | FEN1 | P39748 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877955 | 0.82 | TDP1 (0.57) | KDM4EMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1004574 | 0.82 | KDM4E (0.58) | KDM4EMEN1GAAMAPTKMT2A | |
| SCHEMBL12214127 | 0.79 | KDM4E (0.42) | KDM4EMEN1GAAMAPTKMT2A | |
| SCHEMBL9283073 | 0.79 | KDM4E (0.40) | ERCC5FEN1KDM4EMEN1GAA | |
| SCHEMBL19465023 | 0.78 | NPC1 (0.42) | ERCC5FEN1MEN1MAPTKMT2A | |
| SCHEMBL1258876 | 0.77 | KDM4E (0.41) | KDM4EMEN1GAAMAPTKMT2A | |
| SCHEMBL15304521 | 0.77 | KDM4E (0.41) | KDM4EMEN1GAAMAPTKMT2A | |
| SCHEMBL2935163 | 0.77 | CTBP2 (0.62) | ERCC5FEN1KDM4EMEN1GAA | |
| SCHEMBL9267218 | 0.76 | KDM4E (0.40) | KDM4EMEN1GAAMAPTKMT2A | |
| SCHEMBL436968 | 0.76 | PLA2G2A (0.41) | KDM4EMEN1GAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002090360-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-11-14 | — | — | WO | disclosed |