Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12204885 | 0.90 | CHRM1 (0.50) | DHPSCHRM1IDH1MAPTNPC1 | |
| SCHEMBL31667251 | 0.87 | DHPS (0.46) | DHPSCHRM1IDH1MAPTNPC1 | |
| SCHEMBL29303343 | 0.87 | CHRM1 (0.48) | DHPSCHRM1MAPTNPC1TP53 | |
| SCHEMBL31569013 | 0.85 | DHPS (0.57) | DHPSSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL7698015 | 0.85 | CA12 (0.47) | DHPSCHRM1MAPTNPC1TP53 | |
| SCHEMBL30057596 | 0.84 | KDM4E (0.54) | CHRM1IDH1MAPTNPC1TP53 | |
| SCHEMBL30058616 | 0.80 | NPC1 (0.55) | CHRM1IDH1MAPTNPC1TP53 | |
| SCHEMBL21162380 | 0.80 | NPC1 (0.55) | CHRM1IDH1MAPTNPC1TP53 | |
| SCHEMBL29303397 | 0.79 | CHRM1 (0.42) | DHPSCHRM1MAPTNPC1TP53 | |
| SCHEMBL5259422 | 0.78 | DHPS (0.41) | DHPSTP53ALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002018381-A1 | 6,7-DIHYDRO-PYRROLO[3,4-B]PYRIDIN-5-ONES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2002-03-07 | — | — | WO | claimed |
| WO-2002018381-A1 | 6,7-DIHYDRO-PYRROLO[3,4-B]PYRIDIN-5-ONES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2002-03-07 | — | — | WO | disclosed |