Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691203 | 1.00 | EPHX2 (0.49) | EPHX2IDO1LMNASMN1; SMN2MEN1 | |
| SCHEMBL7690880 | 1.00 | EPHX2 (0.49) | EPHX2IDO1LMNASMN1; SMN2MEN1 | |
| SCHEMBL7693549 | 0.88 | LMNA (0.60) | IDO1LMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7689923 | 0.88 | LMNA (0.60) | IDO1LMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7088260 | 0.88 | MAPK1 (0.53) | IDO1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7085312 | 0.88 | MAPK1 (0.53) | IDO1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7085306 | 0.88 | MAPK1 (0.53) | IDO1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7697784 | 0.87 | HPGD (0.59) | EPHX2LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL7691193 | 0.87 | HPGD (0.59) | EPHX2LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL7697935 | 0.86 | HTR2B (0.51) | IDO1LMNASMN1; SMN2POLBHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291499-B1 | TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE | MERCK & CO., INC. | 2001-09-18 | — | — | US | claimed |
| US-6380205-B1 | QUINAZOLINE THROUGH A C1-C4ALKYL, C1- C4ALKENYL, C1-C4ALKYNYL, C1-C4ALKOXY, AMINO, AMINOC1-C4ALKYL, HYDROXYC1-C4ALKYL, CARBONYL, CYCLOC3-C6ALKYL OR AMINOCARBONYL CHAIN, USEFUL FOR TREATMENT OF THE PAIN | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| US-6291499-B1 | TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE | MERCK & CO., INC. | 2001-09-18 | — | — | US | disclosed |