SCHEMBL7697935

SCHEMBL7697935

O=C(NCc1ccccc1-c1ccccc1)C1CCC(Cc2nc3ccccc3[nH]2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2B P41595 2/20 0.51
IDO1 P14902 1/20 0.50
CHRM1 P11229 1/20 0.48
CHRM3 P20309 1/20 0.48
LMNA P02545 1/20 0.47
SMN1; SMN2 Q16637 4/20 0.46
GRIN2B Q13224 2/20 0.46
HCRTR1 O43613 1/20 0.45
HCRTR2 O43614 1/20 0.45
CHRNB2 P17787 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA4 P43681 1/20 0.43
POLB P06746 2/20 0.42
CNR2 P34972 1/20 0.42
MELK Q14680 1/20 0.42
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
GRIN1 Q05586 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7695005 1.00 HTR2B (0.51) HTR2BIDO1CHRM1CHRM3LMNA
SCHEMBL7693549 0.87 LMNA (0.60) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7689923 0.87 LMNA (0.60) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7691203 0.86 EPHX2 (0.49) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7692302 0.86 EPHX2 (0.49) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7088260 0.86 MAPK1 (0.53) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7085312 0.86 MAPK1 (0.53) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7085306 0.86 MAPK1 (0.53) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7690880 0.86 EPHX2 (0.49) HTR2BIDO1LMNASMN1; SMN2GRIN2B
SCHEMBL7083207 0.85 IDO1 (0.56) HTR2BIDO1SMN1; SMN2GRIN2BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US claimed
US-6380205-B1 QUINAZOLINE THROUGH A C1-C4ALKYL, C1- C4ALKENYL, C1-C4ALKYNYL, C1-C4ALKOXY, AMINO, AMINOC1-C4ALKYL, HYDROXYC1-C4ALKYL, CARBONYL, CYCLOC3-C6ALKYL OR AMINOCARBONYL CHAIN, USEFUL FOR TREATMENT OF THE PAIN MERCK & CO., INC. 2002-04-30 US disclosed
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US disclosed