Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340389 | 0.92 | RAB9A (0.58) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL1339048 | 0.90 | SMN1; SMN2 (0.53) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL1340415 | 0.88 | SMN1; SMN2 (0.53) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL1338618 | 0.88 | SMN1; SMN2 (0.66) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL1340922 | 0.87 | ALOX15 (0.71) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL1339296 | 0.87 | RAB9A (0.55) | SMN1; SMN2LMNATP53TSHRAURKA | |
| SCHEMBL1340599 | 0.87 | POLB (0.53) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL1339917 | 0.86 | SMN1; SMN2 (0.50) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL12129256 | 0.86 | RAB9A (0.49) | MEN1KMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL1341047 | 0.86 | RAB9A (0.56) | MEN1KMT2ASMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | claimed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | claimed |
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | disclosed |