⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3898971 | 0.88 | NOS3 (0.36) | — | |
| SCHEMBL982334 | 0.82 | CYP1A1 (0.37) | — | |
| SCHEMBL913399 | 0.76 | — | — | |
| SCHEMBL30779745 | 0.76 | — | — | |
| SCHEMBL17039219 | 0.73 | NOS3 (0.46) | — | |
| SCHEMBL19062737 | 0.73 | GRM5 (0.39) | — | |
| SCHEMBL64599 | 0.73 | — | — | |
| SCHEMBL16288839 | 0.71 | — | — | |
| SCHEMBL3510212 | 0.71 | — | — | |
| SCHEMBL18737312 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973886-B1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-27 | — | — | EP | claimed |
| US-11396508-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2022-07-26 | — | — | US | disclosed |
| US-20210094948-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-01 | — | — | US | disclosed |
| US-20210094948-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-01 | — | — | US | disclosed |
| EP-3738591-A2 | NOVEL ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3738591-A2 | NOVEL ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2020-11-18 | — | — | EP | disclosed |
| US-10647713-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-10647713-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| CN-110300590-A | TYK2 inhibitor and application thereof | 林伯士拉克许米公司 | 2019-10-01 | — | — | CN | disclosed |
| EP-3528816-A1 | TYK2 INHIBITORS AND USES THEREOF | Nimbus Lakshmi, Inc. (US) | 2019-08-28 | — | — | EP | disclosed |
| US-20090209593-A1 | NOVEL ANTIBACTERIAL AGENTS | TETARD, INC. | 2009-08-20 | — | — | US | disclosed |
| US-20090209593-A1 | NOVEL ANTIBACTERIAL AGENTS | TETARD, INC. | 2009-08-20 | — | — | US | disclosed |
| US-20090209593-A1 | NOVEL ANTIBACTERIAL AGENTS | TETARD, INC. | 2009-08-20 | — | — | US | disclosed |
| EP-1654251-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20060205740-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2006-09-14 | — | — | US | disclosed |
| US-20060100164-A1 | 11-N-[4-(4-Pyridin-3-yl-imidazol-1-yl)-butyl]-6-O-methyl-5-O-(3-dimethylamino-2-hydroxy-propoxy)-3-oxo-erythronolide A, 11,12-carbamate; functionalized macrolides; antiviral, antiprotozoal, anticancer and antigastrointestinal | TETARD, INC. | 2006-05-11 | — | — | US | disclosed |
| EP-1654251-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| EP-1638549-A2 | NOVEL ANTIBACTERIAL AGENTS | Optimer Pharmaceuticals, Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005016914-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2004080391-A2 | NOVEL ANTIBACTERIAL AGENTS | OPTIMER PHARMACEUTICALS, INC. (US) | 2004-09-23 | — | — | WO | disclosed |