SCHEMBL7693138

SCHEMBL7693138

COc1ccccc1CNC(=O)C1CCC(Nc2nc3ccccc3[nH]2)CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.58
POLB P06746 3/20 0.56
LMNA P02545 2/20 0.54
MAPT P10636 2/20 0.54
SMN1; SMN2 Q16637 4/20 0.53
NPC1 O15118 4/20 0.53
RAB9A P51151 4/20 0.53
TP53 P04637 3/20 0.53
TSHR P16473 2/20 0.53
HTT P42858 1/20 0.53
ALDH1A1 P00352 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C19 P33261 1/20 0.51
EPHX2 P34913 1/20 0.48
HSP90AA1 P07900 1/20 0.47
PKM P14618 1/20 0.47
PAX8 Q06710 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7693135 1.00 HPGD (0.58) HPGDPOLBLMNAMAPTSMN1; SMN2
SCHEMBL7691713 1.00 HPGD (0.58) HPGDPOLBLMNAMAPTSMN1; SMN2
SCHEMBL7695496 0.88 EPHX2 (0.55) HPGDPOLBSMN1; SMN2NPC1RAB9A
SCHEMBL7695491 0.88 EPHX2 (0.55) HPGDPOLBSMN1; SMN2NPC1RAB9A
SCHEMBL7696480 0.87 SMN1; SMN2 (0.55) POLBMAPTSMN1; SMN2NPC1RAB9A
SCHEMBL7696476 0.87 SMN1; SMN2 (0.55) POLBMAPTSMN1; SMN2NPC1RAB9A
SCHEMBL7698279 0.86 ALDH1A1 (0.56) POLBLMNASMN1; SMN2NPC1RAB9A
SCHEMBL7698276 0.86 ALDH1A1 (0.56) POLBLMNASMN1; SMN2NPC1RAB9A
SCHEMBL7692146 0.85 LMNA (0.55) POLBLMNAMAPTSMN1; SMN2NPC1
SCHEMBL7692144 0.85 LMNA (0.55) POLBLMNAMAPTSMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US claimed
US-6380205-B1 QUINAZOLINE THROUGH A C1-C4ALKYL, C1- C4ALKENYL, C1-C4ALKYNYL, C1-C4ALKOXY, AMINO, AMINOC1-C4ALKYL, HYDROXYC1-C4ALKYL, CARBONYL, CYCLOC3-C6ALKYL OR AMINOCARBONYL CHAIN, USEFUL FOR TREATMENT OF THE PAIN MERCK & CO., INC. 2002-04-30 US disclosed
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US disclosed