Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696483 | 0.88 | MAPT (0.40) | TDP1MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL7690535 | 0.86 | MAPT (0.38) | TDP1MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL2817995 | 0.82 | TDP1 (0.66) | TDP1MAPTCLCN2ALDH1A1KDM4E | |
| SCHEMBL30949565 | 0.76 | TDP1 (0.55) | TDP1MAPTCLCN2ALDH1A1KDM4E | |
| SCHEMBL6931814 | 0.76 | TDP1 (0.55) | TDP1MAPTCLCN2ALDH1A1KDM4E | |
| SCHEMBL7693240 | 0.75 | MAPT (0.49) | TDP1MAPTCLCN2ALDH1A1KDM4E | |
| SCHEMBL28283707 | 0.74 | TDP1 (0.50) | TDP1MAPTCLCN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7696491 | 0.74 | MAPT (0.48) | TDP1MAPTCLCN2ALDH1A1KDM4E | |
| SCHEMBL18529850 | 0.73 | TDP1 (0.52) | TDP1MAPTCLCN2ALDH1A1KDM4E | |
| SCHEMBL27883374 | 0.73 | MAPT (0.57) | TDP1MAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001053298-A9 | IMIDAZOPYRIDINES AND RELATED AZACYCLIC DERIVATIVES AS SELECTIVE MODULATORS OF BRADYKININ B2 RECEPTORS | NEUROGEN CORP (US) | 2002-10-17 | — | — | WO | disclosed |
| US-6420365-B1 | Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors | NEUROGEN CORPORATION | 2002-07-16 | — | — | US | disclosed |
| WO-2001053298-A1 | IMIDAZOPYRIDINES AND RELATED AZACYCLIC DERIVATIVES AS SELECTIVE MODULATORS OF BRADYKININ B2 RECEPTORS | NEUROGEN CORPORATION (US) | 2001-07-26 | — | — | WO | disclosed |