Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 4/20 | 0.34 |
| ▸ | FNTB | P49356 | 4/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690664 | 0.81 | PSEN1 (0.43) | POLBSLC6A4FNTAFNTB | |
| SCHEMBL10684249 | 0.73 | MTNR1A (0.50) | POLBMEN1KMT2AGRIN2BGBA1 | |
| SCHEMBL12450084 | 0.71 | HSD11B1 (0.38) | MEN1KMT2AFNTAFNTB | |
| SCHEMBL6616133 | 0.70 | MEN1 (0.68) | POLBMEN1KMT2A | |
| SCHEMBL6618053 | 0.70 | MEN1 (0.68) | POLBMEN1KMT2A | |
| SCHEMBL15528548 | 0.70 | RORC (0.32) | SLC6A4 | |
| SCHEMBL7693752 | 0.69 | FNTA (0.38) | KMT2AFNTAFNTB | |
| SCHEMBL7693749 | 0.69 | FNTA (0.38) | KMT2AFNTAFNTB | |
| SCHEMBL7693756 | 0.69 | FNTA (0.38) | KMT2AFNTAFNTB | |
| SCHEMBL17079017 | 0.69 | ACHE (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458783-B1 | INHIBITION OF FARNESYL TRANSFERASE, WHICH IS AN ENZYME INVOLVED IN RAS ONCOGENE EXPRESSION, IS EFFECTED BY COMPOUNDS OF THE FORMULAS OF BENODIAZEPINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-01 | — | — | US | disclosed |
| WO-2001081322-A1 | NON-IMIDAZOLE BENZODIAZEPINE INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |