Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694164 | 1.00 | MAOA (0.44) | MAOAMAOBCHRNA7RIPK1MDM2 | |
| SCHEMBL7590850 | 1.00 | MAOA (0.44) | MAOAMAOBCHRNA7RIPK1MDM2 | |
| Fumaric Acid SCHEMBL7594413 | 0.90 | MAPT (0.40) | MAOAMAOBCHRNA7RIPK1MDM2 | |
| Fumaric Acid SCHEMBL7594410 | 0.90 | MAPT (0.40) | MAOAMAOBCHRNA7RIPK1MDM2 | |
| Fumaric Acid SCHEMBL7590876 | 0.90 | MAPT (0.40) | MAOAMAOBCHRNA7RIPK1MDM2 | |
| SCHEMBL7590715 | 0.80 | MAOA (0.44) | MAOAMAOBCHRNA7RIPK1MDM2 | |
| SCHEMBL7590719 | 0.80 | MAOA (0.44) | MAOAMAOBCHRNA7RIPK1MDM2 | |
| Hydrochloric Acid SCHEMBL7590235 | 0.76 | RIPK1 (0.44) | MAOAMAOBCHRNA7RIPK1SLC9A1 | |
| Hydrochloric Acid SCHEMBL7590233 | 0.76 | RIPK1 (0.44) | MAOAMAOBCHRNA7RIPK1SLC9A1 | |
| SCHEMBL20187570 | 0.72 | SLC6A2 (0.47) | SLC9A1HTR2AHTR2CHTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451789-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS | LES LABORTOIRES SERVIER (FR) | 2002-09-17 | — | — | US | disclosed |
| US-6323222-B1 | COGNITION ACTIVATORS, ALZHEIMER*S DISEASE AND ENZYME INHIBITORS | ADIR ET COMPAGNIE (FR) | 2001-11-27 | — | — | US | disclosed |