Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6117652 | 0.97 | ALDH1A1 (0.37) | ALDH1A1TSHRL3MBTL1THRBNOS1 | |
| Trifluoroacetic Acid SCHEMBL1262416 | 0.85 | — | — | |
| Trifluoroacetic Acid SCHEMBL72727 | 0.85 | — | — | |
| Trifluoroacetic Acid SCHEMBL3499424 | 0.85 | — | — | |
| Trifluoroacetic Acid SCHEMBL2484766 | 0.84 | ALDH1A1 (0.44) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL4598430 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL30657022 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL474 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL7814389 | 0.84 | ALDH1A1 (0.44) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL1731636 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738591-A2 | NOVEL ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2020-11-18 | — | — | EP | disclosed |
| CN-107405319-A | Antifibrinolysis compound | 希罗姆波尔蒂克斯有限责任公司 | 2017-11-28 | — | — | CN | disclosed |
| US-20160280718-A1 | NOVEL ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME (US) | 2016-09-29 | — | — | US | disclosed |
| US-9200026-B2 | Antibacterial agents | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| EP-2664331-B1 | Novel Antibacterial Agents | MERCK SHARP & DOHME (US) | 2015-09-16 | — | — | EP | disclosed |
| EP-2772254-A2 | Novel Antibacterial Agents | Optimer Pharmaceuticals, Inc. (US) | 2014-09-03 | — | — | EP | disclosed |
| US-20130345410-A1 | NOVEL ANTIBACTERIAL AGENTS | OPTIMER PHARMACEUTICALS, INC. (US) | 2013-12-26 | — | — | US | disclosed |
| EP-2664331-A1 | Novel Antibacterial Agents | Optimer Pharmaceuticals, Inc. (US) | 2013-11-20 | — | — | EP | disclosed |
| US-8343936-B2 | Antibacterial agents | OPTIMER PHARMACEUTICALS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20120071429-A1 | Novel antibacterial agents | TETARD, INC. | 2012-03-22 | — | — | US | disclosed |
| WO-1997007131-A1 | ACYLATED OLIGOPEPTIDES CONTAINING PHOSPHOTYROSINE AS INHIBITORS OF PROTEIN TYROSINE KINASES | NOVARTIS AG (CH) | 1997-02-27 | — | — | WO | disclosed |
| US-5459063-A | Antimalarial agents | THE UNIVERSITY OF PENNSYLVANIA (US) | 1995-10-17 | — | — | US | disclosed |
| US-5254682-A | Treating hypertension, hyperaldosteronism, congestive heart failure; glaucoma | MERCK & CO., INC. (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0518675-A2 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0518672-A2 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0435996-A4 | MODIFIED TRANSFORMING GROWTH FACTOR -G(A) OLIGOPEPTIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | — | 1992-07-29 | — | — | EP | disclosed |
| EP-0435996-A1 | MODIFIED TRANSFORMING GROWTH FACTOR $g(a) OLIGOPEPTIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE ROCKEFELLER UNIVERSITY (US) | 1991-07-10 | — | — | EP | disclosed |
| EP-0432974-A1 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1991-06-19 | — | — | EP | disclosed |
| EP-0431972-A2 | Macrocyclic lactones having renin inhibiting properties | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| WO-1991001141-A1 | MODIFIED TRANSFORMING GROWTH FACTOR α OLIGOPEPTIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE ROCKEFELLER UNIVERSITY (US) | 1991-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345410-A1 | NOVEL ANTIBACTERIAL AGENTS | MRPL21, CTSA, MRPL12 | ALDH1A1 4594/4885TSHR 3227/4885L3MBTL1 2037/4885 |
| US-20160280718-A1 | NOVEL ANTIBACTERIAL AGENTS | MRPL21, MRPL12, CTSA | ALDH1A1 4735/4885TSHR 3235/4885L3MBTL1 2103/4885 |
| US-20120071429-A1 | Novel antibacterial agents | MRPL21, CTSA, MRPL12 | ALDH1A1 4594/4885TSHR 3227/4885L3MBTL1 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.