SCHEMBL769483

SCHEMBL769483

CC(C)(C)c1cc(-n2nc3ccc(S(=O)(=O)c4ccccc4)cc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.37
HSD11B1 P28845 2/20 0.36
CNR2 P34972 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
TSHR P16473 1/20 0.36
CYP2C19 P33261 1/20 0.36
PTGS2 P35354 5/20 0.36
ALOX5 P09917 2/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
ALDH1A1 P00352 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NR1I2 O75469 2/20 0.32
HTR6 P50406 1/20 0.32
FEN1 P39748 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29357045 1.00 POLB (0.37) POLBHSD11B1CNR2CYP1A2CYP3A4
SCHEMBL8351052 0.94 POLB (0.35) POLBCYP1A2CYP3A4CYP2C9TSHR
SCHEMBL9259309 0.90 NR1I2 (0.32) POLBPTGS2ALOX5NPC1RAB9A
SCHEMBL9263512 0.90 NR1I2 (0.36) POLBHSD11B1PTGS2ALOX5NPC1
SCHEMBL9265042 0.90 NR1I2 (0.36) POLBHSD11B1CNR2CYP3A4NPC1
SCHEMBL9265339 0.90 KMT2A (0.37) POLBCYP1A2CYP3A4CYP2C9TSHR
SCHEMBL21586972 0.90 POLB (0.37) POLBHSD11B1CNR2PTGS2NPC1
SCHEMBL21586956 0.89 POLB (0.46) POLBHSD11B1CNR2PTGS2NPC1
SCHEMBL30397522 0.89 POLB (0.46) POLBHSD11B1CNR2PTGS2NPC1
SCHEMBL5834568 0.87 POLB (0.35) POLBHSD11B1CNR2CYP3A4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 694 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6391949-B1 None US claimed
JP-4705249-B2 2011-06-22 JP claimed
EP-1175467-B1 STABILIZED ADHESIVE COMPOSITIONS CONTAINING HIGHLY SOLUBLE, RED-SHIFTED, PHOTOSTABLE BENZOTRIAZOLE UV ABSORBERS AND LAMINATED ARTICLES DERIVED THEREFROM CIBA SC HOLDING AG (CH) 2006-06-14 EP claimed
US-20050123691-A1 Photo-cured and stabilized coatings SUHADOLNIK JOSEPH (US) 2005-06-09 US claimed
US-6800676-B2 ULTRAVIOLET RADIATION ABSORBERS; HEAT AND OXIDATION RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2004-10-05 US claimed
US-20040191447-A1 storage of food, beverages, drugs or cosmetics in radiation transparent plastic containers having coatings comprising stabilizer agents selected from hydroxyphenyl benzotriazole ultraviolet radiation absorber materials ANDREWS STEPHEN M (US) 2004-09-30 US claimed
US-6797751-B2 A CLEAR OR LIGHTLY COLORED PLASTIC CONTAINERS OR FILMS COMPRISING A BENZOTRIAZOLES OR TRIS-ARYL-S-TRIAZINES STABILIZER; PROTECTIVE DEVICES FOR FOODS, BEVERAGES, DRUGS, COSMETICS, SHAMPOO CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-28 US claimed
EP-1448613-A1 CURABLE MIXTURES COMPRISING UV-ABSORBER, ACYLPHOSPHINOXIDE AND HYDROXY KETONE PHOTOINITIATOR Ciba SC Holding AG (CH) 2004-08-25 EP claimed
US-6638997-B2 Used for stabilizing polyolefin and automotive coating formulation against the deleterious effects of oxidative, thermal and actinic radiation CIBA SPECIALTY CHEMICALS CORPORATION 2003-10-28 US claimed
US-20030144389-A1 Method of content protection with durable UV absorbers ANDREWS STEPHEN MARK (US) 2003-07-31 US claimed
EP-0704560-A1 Stabilization of pigmented fiber with a synergistic mixture of hindered amine and UV absorber CIBA-GEIGY AG (CH) 1996-04-03 EP claimed
EP-0698637-A2 Polyurethanes stabilized with selected 5-substituted benzotriazole UV absorbers CIBA-GEIGY AG (CH) 1996-02-28 EP claimed
US-5436349-A Photostabilizers for polymers for radiation resistance CIBA-GEIGY CORPORATION (US) 1995-07-25 US claimed
US-5319091-A Contacting sulfur-containing aromatic compound with hydroxyphenylbenzotriazole derivative in presence of polar organic compound, oxidizing formed aryl sulfide derivative to sulfone, sulfoxide or mixtures PHILLIPS PETROLEUM COMPANY (US) 1994-06-07 US claimed
EP-0599269-A1 Compositions comprising sulfur-containing derivatives of hydroxyphenylbenzotriazole and process therefor PHILLIPS PETROLEUM COMPANY (US) 1994-06-01 EP claimed
US-5280124-A Having a phenol structure in position 2 CIBA-GEIGY CORPORATION (US) 1994-01-18 US claimed
US-5274015-A And a polyarylene sulfide polymer PHILLIPS PETROLEUM COMPANY (US) 1993-12-28 US claimed
EP-0572554-A1 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLE UV-ABSORBERS AND STABILIZED COMPOSITIONS Ciba SC Holding AG (CH) 1993-12-08 EP claimed
US-5268450-A Reating sodium hydrosulfide with a sulfur containing hydroxyphenylbenztriazole PHILLIPS PETROLEUM COMPANY (US) 1993-12-07 US claimed
WO-1992014717-A1 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLE UV-ABSORBERS AND STABILIZED COMPOSITIONS CIBA-GEIGY AG (CH) 1992-09-03 WO claimed