SCHEMBL9265339

SCHEMBL9265339

CC(C)(C)c1cc(-n2nc3ccc(S(=O)(=O)c4ccc(N)cc4)cc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.37
MEN1 O00255 5/20 0.37
ALDH1A1 P00352 6/20 0.35
HTR6 P50406 3/20 0.35
PKM P14618 3/20 0.35
HSP90AA1 P07900 1/20 0.34
CYP3A4 P08684 2/20 0.34
LMNA P02545 2/20 0.34
MPO P05164 1/20 0.34
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
HKDC1 Q2TB90 1/20 0.34
NPC1 O15118 3/20 0.33
MAPT P10636 4/20 0.33
CYP2C19 P33261 2/20 0.33
CYP1A2 P05177 1/20 0.33
NR1I2 O75469 4/20 0.32
POLB P06746 2/20 0.32
RAB9A P51151 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8351052 0.93 POLB (0.35) KMT2AMEN1ALDH1A1HSP90AA1CYP3A4
SCHEMBL29357045 0.90 POLB (0.37) ALDH1A1HTR6CYP3A4CYP2C9TSHR
SCHEMBL769483 0.90 POLB (0.37) ALDH1A1HTR6CYP3A4CYP2C9TSHR
SCHEMBL9263512 0.89 NR1I2 (0.36) KMT2AMEN1HSP90AA1LMNANPC1
SCHEMBL9259309 0.89 NR1I2 (0.32) HSP90AA1NPC1NR1I2POLBRAB9A
SCHEMBL9265042 0.89 NR1I2 (0.36) ALDH1A1CYP3A4LMNANPC1MAPT
SCHEMBL27958361 0.85 MEN1 (0.43) KMT2AMEN1ALDH1A1PKMHSP90AA1
SCHEMBL9266779 0.82 MEN1 (0.35) KMT2AMEN1ALDH1A1HSP90AA1NPC1
SCHEMBL23636578 0.81 ACSS2 (0.38) KMT2AMEN1ALDH1A1HSP90AA1CYP3A4
SCHEMBL9266221 0.81 HSP90AA1 (0.36) KMT2AMEN1ALDH1A1HSP90AA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5319091-A Contacting sulfur-containing aromatic compound with hydroxyphenylbenzotriazole derivative in presence of polar organic compound, oxidizing formed aryl sulfide derivative to sulfone, sulfoxide or mixtures PHILLIPS PETROLEUM COMPANY (US) 1994-06-07 US claimed
EP-0599269-A1 Compositions comprising sulfur-containing derivatives of hydroxyphenylbenzotriazole and process therefor PHILLIPS PETROLEUM COMPANY (US) 1994-06-01 EP claimed
US-5274015-A And a polyarylene sulfide polymer PHILLIPS PETROLEUM COMPANY (US) 1993-12-28 US claimed
US-5410071-A Sulfiding with a thiophenolic compound or a thiophenolate in a polar solvent to form a stabilizers for polyphenylene sulfide against UV radiation PHILLIPS PETROLEUM COMPANY (US) 1995-04-25 US disclosed
US-5319091-A Contacting sulfur-containing aromatic compound with hydroxyphenylbenzotriazole derivative in presence of polar organic compound, oxidizing formed aryl sulfide derivative to sulfone, sulfoxide or mixtures PHILLIPS PETROLEUM COMPANY (US) 1994-06-07 US disclosed
EP-0599269-A1 Compositions comprising sulfur-containing derivatives of hydroxyphenylbenzotriazole and process therefor PHILLIPS PETROLEUM COMPANY (US) 1994-06-01 EP disclosed
US-5274015-A And a polyarylene sulfide polymer PHILLIPS PETROLEUM COMPANY (US) 1993-12-28 US disclosed
US-5268450-A Reating sodium hydrosulfide with a sulfur containing hydroxyphenylbenztriazole PHILLIPS PETROLEUM COMPANY (US) 1993-12-07 US disclosed