Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.70 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.70 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.61 |
| ▸ | NOD1 | Q9Y239 | 7/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10935016 | 1.00 | PTGS1 (0.70) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| SCHEMBL13561368 | 1.00 | PTGS1 (0.70) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| SCHEMBL1514772 | 1.00 | PTGS1 (0.70) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| SCHEMBL20077367 | 0.88 | PTGS1 (0.68) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| SCHEMBL22015916 | 0.87 | PTGS1 (0.67) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| SCHEMBL22015845 | 0.86 | PTGS1 (0.65) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| Glutathione SCHEMBL3747118 | 0.86 | PTGS1 (0.90) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| Glutathione SCHEMBL1237560 | 0.86 | PTGS1 (0.90) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| Glutathione SCHEMBL3747125 | 0.86 | PTGS1 (0.90) | PTGS1GSTK1GLO1NOD1FOLH1 | |
| Glutathione SCHEMBL27807172 | 0.85 | PTGS1 (0.88) | PTGS1GSTK1GLO1NOD1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60232071-A | — | — | None | — | — | JP | disclosed |
| US-8551963-B2 | Imidazolothiazole compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120070410-A1 | IMIDAZOLOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION | 2012-03-22 | — | — | US | disclosed |
| EP-2358725-A1 | Imidazolothiazole compounds as modulators of protein kinase | Ambit Biosciences Corporation (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010054058-A1 | IMIDAZOLOTHIAZOLE COMPOUNDS AS MODULATORS OF PROTEIN KINASE | AMBIT BIOSCIENCE CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |
| US-20050008665-A1 | Cosmetic or dermatological active ingredient combination | BEIERSDORF AG | 2005-01-13 | — | — | US | disclosed |
| EP-1455744-A2 | COSMETIC AND/OR DERMATOLOGICAL ACTIVE INGREDIENT COMBINATION | Beiersdorf AG (DE) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003032941-A2 | COSMETIC AND/OR DERMATOLOGICAL ACTIVE INGREDIENT COMBINATION | BEIERSDORF AG (DE) | 2003-04-24 | — | — | WO | disclosed |
| JP-S60232071-A | PREPARATION OF SEASONING HAVING GOOD BODY, AND FOOD HAVING IMPROVED BODY | AJINOMOTO CO INC | 1985-11-18 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008665-A1 | Cosmetic or dermatological active ingredient combination | SDHA, CUTA, HDAC8 | PTGS1 779/4885GSTK1 506/4885GLO1 671/4885 |
| US-20120070410-A1 | IMIDAZOLOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GRK2, GRK3, GRK4 | PTGS1 1156/4885GSTK1 376/4885GLO1 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.