Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7173507 | 0.99 | NR1H4 (0.56) | NR1H4HTTLMNASMN1; SMN2TP53 | |
| SCHEMBL7694862 | 0.92 | NR1H4 (0.56) | NR1H4HTTLMNASMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL7173503 | 0.91 | NR1H4 (0.56) | NR1H4HTTLMNASMN1; SMN2TP53 | |
| SCHEMBL7134761 | 0.87 | LMNA (0.51) | HTTLMNASMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7130689 | 0.86 | LMNA (0.50) | HTTLMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7134799 | 0.86 | LMNA (0.45) | HTTLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7133459 | 0.85 | LMNA (0.48) | HTTLMNASMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7699759 | 0.85 | LMNA (0.45) | HTTLMNASMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7155908 | 0.84 | LMNA (0.47) | HTTLMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7129862 | 0.80 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420391-B1 | PREVENTION AND/OR TREATMENT OF VARIOUS INFLAMMATORY DISEASES, SEPSIS, MULTIPLE MYELOMA, PLASMA CELL LEUKEMIA, OSTEOPOROSIS, CACHEXIA, PSORIASIS, NEPHRITIS, RENAL CELL CARCINOMA, KAPOSI'S SARCOMA, RHEUMATOID ARTHRITIS, GAMMOPATHY, CASTLEMAN'S | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1067128-A1 | FUSED THIOPHENE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | claimed |