Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712068 | 0.88 | RAB9A (0.67) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL27926814 | 0.85 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL17468789 | 0.82 | RAB9A (0.61) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL27863664 | 0.80 | CYP1A2 (0.65) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL17482192 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL17482180 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL3780684 | 0.78 | HTT (0.61) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL27863645 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL31655490 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL3661523 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342589-B1 | REACTING 3,6-BIS(3,5-DIMETHYLPYRAZOL-1-YL)-1,2,4,5-TETRAZINE WITH HYDRAZINE; FURTHER REACTING WITH N-BROMOSUCCINIMIDE IN ACETONITRILE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY | 2002-01-29 | — | — | US | disclosed |