Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133437 | 0.92 | KMT2A (0.46) | SMN1; SMN2HTR6KMT2AMEN1KDM4E | |
| SCHEMBL7696310 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR6KAT6ABCHEKMT2A | |
| SCHEMBL7132601 | 0.87 | PKM (0.38) | SMN1; SMN2BCHEKMT2AKDM4EALDH1A1 | |
| SCHEMBL7693051 | 0.86 | KMT2A (0.46) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7160031 | 0.85 | KMT2A (0.45) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7135184 | 0.85 | KDM4E (0.41) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL7127514 | 0.84 | CXCR4 (0.38) | HTR6BCHEKMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7158389 | 0.84 | KDM4E (0.41) | KMT2AMEN1KDM4EALDH1A1CA1 | |
| SCHEMBL7129574 | 0.83 | MEN1 (0.42) | SMN1; SMN2HTR6KMT2AMEN1KDM4E | |
| SCHEMBL7130582 | 0.81 | SSTR3 (0.37) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420391-B1 | PREVENTION AND/OR TREATMENT OF VARIOUS INFLAMMATORY DISEASES, SEPSIS, MULTIPLE MYELOMA, PLASMA CELL LEUKEMIA, OSTEOPOROSIS, CACHEXIA, PSORIASIS, NEPHRITIS, RENAL CELL CARCINOMA, KAPOSI'S SARCOMA, RHEUMATOID ARTHRITIS, GAMMOPATHY, CASTLEMAN'S | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |