Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133441 | 0.92 | KMT2A (0.44) | SMN1; SMN2HTR6BCHEKMT2AMEN1 | |
| SCHEMBL7696309 | 0.90 | SMN1; SMN2 (0.45) | SMN1; SMN2HTR6BCHEKMT2AMEN1 | |
| SCHEMBL7132604 | 0.86 | CA1 (0.37) | SMN1; SMN2BCHEALDH1A1CA1CA2 | |
| SCHEMBL7693053 | 0.86 | KMT2A (0.46) | SMN1; SMN2HTR6KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL7160026 | 0.85 | KMT2A (0.45) | SMN1; SMN2HTR6KMT2AMEN1KDM4E | |
| SCHEMBL7135186 | 0.85 | KDM4E (0.40) | KMT2AMEN1KDM4ECA1CA2 | |
| Hydrochloric Acid SCHEMBL7158383 | 0.84 | KDM4E (0.39) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7127515 | 0.84 | HTR6 (0.36) | HTR6BCHEKMT2AKDM4EALDH1A1 | |
| SCHEMBL7129579 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR6KMT2AMEN1KDM4E | |
| SCHEMBL7123801 | 0.82 | RAB9A (0.36) | SMN1; SMN2KDM4EALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420391-B1 | PREVENTION AND/OR TREATMENT OF VARIOUS INFLAMMATORY DISEASES, SEPSIS, MULTIPLE MYELOMA, PLASMA CELL LEUKEMIA, OSTEOPOROSIS, CACHEXIA, PSORIASIS, NEPHRITIS, RENAL CELL CARCINOMA, KAPOSI'S SARCOMA, RHEUMATOID ARTHRITIS, GAMMOPATHY, CASTLEMAN'S | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |