Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699072 | 0.84 | GPR119 (0.38) | GPR119JAK2JAK1BCL2A1CYP2D6 | |
| SCHEMBL7697640 | 0.83 | CYP3A4 (0.41) | GPR119JAK2JAK1NR1H2NR1H3 | |
| SCHEMBL7694462 | 0.81 | GPR119 (0.37) | GPR119JAK2JAK1BCL2A1CYP2D6 | |
| SCHEMBL7701147 | 0.80 | GPR119 (0.41) | GPR119JAK2JAK1BCL2A1CYP2D6 | |
| SCHEMBL7701110 | 0.78 | GPR119 (0.38) | GPR119JAK2JAK1BCL2A1NR1H2 | |
| SCHEMBL7701036 | 0.78 | BCL2A1 (0.42) | GPR119JAK2JAK1BCL2A1CYP2D6 | |
| SCHEMBL7697124 | 0.78 | GPR119 (0.37) | GPR119JAK2JAK1BCL2A1CYP2D6 | |
| SCHEMBL7693272 | 0.77 | CYP2D6 (0.36) | BCL2A1CYP2D6SLC6A2SLC6A4NOS2 | |
| SCHEMBL7702610 | 0.74 | GPR119 (0.37) | GPR119JAK2JAK1BCL2A1CYP2D6 | |
| SCHEMBL23203086 | 0.70 | RORC (0.41) | GPR119JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002012187-A1 | NOVEL PHENYLHETEROAZETIDINES, USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |