SCHEMBL769651

SCHEMBL769651

N#Cc1cc(F)c(Cl)cc1C#N

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KHK P50053 1/20 0.48
TRPV4 Q9HBA0 4/20 0.46
ALDH1A1 P00352 2/20 0.43
CYP2D6 P10635 2/20 0.42
SLC6A2 P23975 2/20 0.42
SLC6A4 P31645 2/20 0.42
NOS2 P35228 2/20 0.42
MAPK1 P28482 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.39
CYP11B2 P19099 4/20 0.38
CYP11B1 P15538 1/20 0.37
TDP1 Q9NUW8 1/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
VCAM1 P19320 1/20 0.34
AR P10275 1/20 0.34
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29513067 0.88 TRPV4 (0.50) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL286611 0.88 TRPV4 (0.50) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL7931517 0.88 ALDH1A1 (0.46) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL30110369 0.88 ALDH1A1 (0.50) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL7575800 0.88 ALDH1A1 (0.50) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL31504178 0.88 TRPV4 (0.56) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL1880028 0.88 TRPV4 (0.56) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL10947192 0.83 TRPV4 (0.56) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL405495 0.82 KHK (0.47) KHKTRPV4ALDH1A1CYP2D6SLC6A2
SCHEMBL28867592 0.82 ESR1 (0.41) KHKTRPV4ALDH1A1CYP2D6SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102449795-A Use of phthalocyanine compounds with aryl or heteroaryl substituents in organic solar cells BASF SE 2012-05-09 CN disclosed
US-20120068123-A1 USE OF PHTHALOCYANINE COMPOUNDS WITH ARYL OR HETARYL SUBSTITUENTS IN ORGANIC SOLAR CELLS BASF SE (DE) 2012-03-22 US disclosed
US-20120068123-A1 USE OF PHTHALOCYANINE COMPOUNDS WITH ARYL OR HETARYL SUBSTITUENTS IN ORGANIC SOLAR CELLS BASF SE (DE) 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120068123-A1 USE OF PHTHALOCYANINE COMPOUNDS WITH ARYL OR HETARYL SUBSTITUENTS IN ORGANIC SOLAR CELLS RB1, NRAS, HLA-B KHK 2671/4885TRPV4 694/4885ALDH1A1 761/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.