Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.54 |
| ▸ | HTR1D | P28221 | 8/20 | 0.54 |
| ▸ | HTR1B | P28222 | 8/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | HTR6 | P50406 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701118 | 0.86 | KDR (0.61) | NAMPTCHEK1KDR | |
| SCHEMBL7704717 | 0.85 | KDR (0.55) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL7701734 | 0.84 | CHEK1 (0.58) | NAMPTCHEK1KDR | |
| SCHEMBL6998816 | 0.83 | GLA (0.55) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL7704101 | 0.83 | CHEK1 (0.57) | NAMPTCHEK1RAB9AKDR | |
| SCHEMBL7002937 | 0.82 | CHEK1 (0.61) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL7701651 | 0.82 | KDM4E (0.57) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL7094822 | 0.81 | KDR (0.56) | NAMPTCHEK1KDR | |
| SCHEMBL7000769 | 0.76 | CHEK1 (0.64) | HTR2CCHEK1RAB9AKDR | |
| SCHEMBL7698438 | 0.76 | LMNA (0.58) | NAMPTCHEK1MAPTGAAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |