Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836430 | 0.80 | CHEK1 (0.49) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7698793 | 0.79 | RAB9A (0.48) | KDRCHEK1CDK1CDK2OPRD1 | |
| SCHEMBL7094187 | 0.78 | CHEK1 (0.53) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7835370 | 0.78 | CHEK1 (0.51) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7840336 | 0.78 | CHEK1 (0.57) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7094279 | 0.77 | KDR (0.58) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7184665 | 0.77 | CHEK1 (0.51) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7832418 | 0.77 | CHEK1 (0.51) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7832382 | 0.76 | CHEK1 (0.52) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7832987 | 0.75 | CHEK1 (0.54) | KDRCHEK1CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |