Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702887 | 0.80 | HPGD (0.53) | RAB9AKDRCHEK1ALDH1A1NAMPT | |
| SCHEMBL7696947 | 0.79 | KDR (0.47) | KDRCHEK1CDK1CDK2OPRD1 | |
| SCHEMBL7701963 | 0.78 | CHEK1 (0.57) | KDRCHEK1KCNH2CDK1CDK2 | |
| SCHEMBL7704058 | 0.77 | CHRM3 (0.54) | CHEK1 | |
| SCHEMBL7698769 | 0.77 | KDR (0.58) | KDRCHEK1KCNH2NAMPTCDK1 | |
| SCHEMBL7696882 | 0.77 | CHEK1 (0.51) | MCHR1KDRCHEK1KCNH2NAMPT | |
| Urea SCHEMBL7696206 | 0.76 | MEN1 (0.52) | KDRCHEK1KCNH2CDK1CDK2 | |
| SCHEMBL7701206 | 0.75 | CHEK1 (0.49) | KDRCHEK1KCNH2CDK1CDK2 | |
| SCHEMBL7000769 | 0.75 | CHEK1 (0.64) | RAB9AKDRCHEK1CDK1CDK2 | |
| SCHEMBL7698455 | 0.75 | CHEK1 (0.56) | RAB9ASMN1; SMN2KDRCHEK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |