SCHEMBL76978

SCHEMBL76978

CC1=C(c2ccccc2NS(=O)(=O)c2ccc(C)cc2)C(=O)CC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.67
ALDH1A1 P00352 3/20 0.67
CYP2C9 P11712 2/20 0.67
CYP2C19 P33261 2/20 0.67
MAPT P10636 2/20 0.67
L3MBTL1 Q9Y468 2/20 0.67
USP2 O75604 1/20 0.67
POLB P06746 1/20 0.67
NOD2 Q9HC29 1/20 0.67
CA2 P00918 3/20 0.60
CA9 Q16790 3/20 0.60
CA12 O43570 2/20 0.60
MCOLN3 Q8TDD5 2/20 0.60
KEAP1 Q14145 1/20 0.55
NFE2L2 Q16236 1/20 0.55
CA1 P00915 2/20 0.51
CA4 P22748 1/20 0.51
CA7 P43166 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.49
TSHR P16473 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL77967 0.87 LMNA (0.51) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL78542 0.83 KMT2A (0.45) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL79131 0.83 MAPT (0.47) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL77762 0.82 LMNA (0.62) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL78568 0.79 LMNA (0.67) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL9902123 0.77 LMNA (0.91) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL2068526 0.76 LMNA (0.82) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL2516997 0.76 LMNA (1.00) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL31207793 0.76 LMNA (1.00) LMNAALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL2069805 0.75 LMNA (0.84) LMNAALDH1A1CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129488-B2 Transition metal complexes, catalyst compositions containing the same, and olefin polymerization using the catalyst compositions LG CHEM, LTD. (KR) 2012-03-06 US disclosed
US-20090209712-A1 TRANSITION METAL COMPLEXES, CATALYST COMPOSITIONS CONTAINING THE SAME, AND OLEFIN POLYMERIZATION USING THE CATALYST COMPOSITIONS LG CHEM., LTD. (KR) 2009-08-20 US disclosed
US-7538239-B2 Transition metal complexes, catalyst compositions containing the same, and olefin polymerization using the catalyst compositions LG CHEM, LTD. (KR) 2009-05-26 US disclosed
WO-2007007992-A1 TRANSITION METAL COMPLEXES, CATALYST COMPOSITIONS CONTAINING THE SAME, AND OLEFIN POLYMERIZATION USING THE CATALYST COMPOSITIONS LG CHEM, LTD. (KR) 2007-01-18 WO disclosed
US-20070010637-A1 Transition metal complexes, catalyst compositions containing the same, and olefin polymerization using the catalyst compositions LG CHEM, LTD. (KR) 2007-01-11 US disclosed