Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.43 |
| ▸ | HHAT | Q5VTY9 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702539 | 0.86 | PRCP (0.46) | PRCPHHATTRPM8CYP2D6CHRM3 | |
| SCHEMBL7701133 | 0.86 | PRCP (0.54) | PRCPHHATCYP2D6CHRM3HDAC8 | |
| SCHEMBL7704956 | 0.84 | CHRM3 (0.47) | PRCPHHATSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7699278 | 0.83 | HDAC1 (0.51) | PRCPMAPTHDAC8HDAC3HDAC1 | |
| SCHEMBL7697839 | 0.83 | PRCP (0.43) | PRCPHHATTRPM8CYP2D6CHRM3 | |
| SCHEMBL7701159 | 0.83 | TRPM8 (0.39) | PRCPHHATTRPM8CYP2D6CHRM3 | |
| SCHEMBL7699731 | 0.82 | PRCP (0.42) | PRCPHHATTRPM8CYP2D6CHRM3 | |
| SCHEMBL7698116 | 0.81 | TRPM8 (0.45) | PRCPHHATTRPM8CYP2D6HDAC8 | |
| SCHEMBL7705576 | 0.81 | PRCP (0.41) | PRCPHHATTRPM8CYP2D6CHRM3 | |
| SCHEMBL7705610 | 0.81 | TRPM8 (0.53) | TRPM8HDAC8HDAC3HDAC1NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |