Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | HHAT | Q5VTY9 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698116 | 0.89 | TRPM8 (0.45) | PRCPHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7704956 | 0.89 | CHRM3 (0.47) | PRCPHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7702539 | 0.89 | PRCP (0.46) | PRCPHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7705610 | 0.86 | TRPM8 (0.53) | HDAC8HDAC3HDAC1NCOR2 | |
| SCHEMBL7705909 | 0.86 | CYP19A1 (0.44) | PRCPHDAC8 | |
| SCHEMBL7705576 | 0.86 | PRCP (0.41) | PRCPHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7699278 | 0.86 | HDAC1 (0.51) | PRCPHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7697965 | 0.86 | PRCP (0.43) | PRCPHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7697839 | 0.86 | PRCP (0.43) | PRCPHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7703888 | 0.85 | PRCP (0.39) | PRCPHDAC8HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |