Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.71 |
| ▸ | NPC1 | O15118 | 11/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12326827 | 0.89 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL25044558 | 0.85 | L3MBTL1 (0.69) | RAB9AKDM4ELMNAALDH1A1HDAC2 | |
| SCHEMBL21100312 | 0.84 | KDM4E (0.62) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7701024 | 0.84 | RAB9A (0.72) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL7703395 | 0.83 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL7704280 | 0.82 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL7705702 | 0.82 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL26765032 | 0.81 | KDM4E (0.61) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL9072710 | 0.81 | KDM4E (0.68) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL12143427 | 0.80 | KDM4E (0.72) | MAPTKMT2AKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |