SCHEMBL7698232

SCHEMBL7698232

O=C(NCc1c(Cl)cccc1Cl)C1CCC(Cc2nc3ccccc3[nH]2)CC1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.51
LMNA P02545 3/20 0.49
SMN1; SMN2 Q16637 4/20 0.49
HTR2B P41595 2/20 0.47
GRIN2B Q13224 1/20 0.46
KDM4E B2RXH2 1/20 0.45
POLB P06746 2/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
LPAR2 Q9HBW0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7697551 1.00 IDO1 (0.51) IDO1LMNASMN1; SMN2HTR2BGRIN2B
SCHEMBL7689923 0.90 LMNA (0.60) IDO1LMNASMN1; SMN2HTR2BGRIN2B
SCHEMBL7693549 0.90 LMNA (0.60) IDO1LMNASMN1; SMN2HTR2BGRIN2B
SCHEMBL7692414 0.89 POLB (0.54) IDO1LMNASMN1; SMN2HTR2BGRIN2B
SCHEMBL7692413 0.89 POLB (0.54) IDO1LMNASMN1; SMN2HTR2BGRIN2B
SCHEMBL7697779 0.87 TP53 (0.51) IDO1SMN1; SMN2GRIN2BKDM4EPOLB
SCHEMBL7695551 0.87 TP53 (0.51) IDO1SMN1; SMN2GRIN2BKDM4EPOLB
SCHEMBL7083207 0.87 IDO1 (0.56) IDO1SMN1; SMN2HTR2BGRIN2B
SCHEMBL7083210 0.87 IDO1 (0.56) IDO1SMN1; SMN2HTR2BGRIN2B
SCHEMBL7682709 0.87 IDO1 (0.56) IDO1SMN1; SMN2HTR2BGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US claimed
US-6380205-B1 QUINAZOLINE THROUGH A C1-C4ALKYL, C1- C4ALKENYL, C1-C4ALKYNYL, C1-C4ALKOXY, AMINO, AMINOC1-C4ALKYL, HYDROXYC1-C4ALKYL, CARBONYL, CYCLOC3-C6ALKYL OR AMINOCARBONYL CHAIN, USEFUL FOR TREATMENT OF THE PAIN MERCK & CO., INC. 2002-04-30 US disclosed
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US disclosed