Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233249 | 0.80 | MPO (0.49) | KDM4EALDH1A1MAPTGAAMPO | |
| SCHEMBL7697931 | 0.79 | MPO (0.48) | KDM4EALDH1A1TDP1MAPTGAA | |
| SCHEMBL6778177 | 0.77 | MPO (0.47) | KDM4EALDH1A1MAPTGAAMPO | |
| SCHEMBL20521730 | 0.77 | MPO (0.47) | KDM4EALDH1A1MAPTGAAMPO | |
| SCHEMBL7703560 | 0.77 | MPO (0.47) | KDM4EALDH1A1MAPTGAAMPO | |
| SCHEMBL7697875 | 0.76 | MPO (0.47) | ALDH1A1TDP1MAPTGAAMPO | |
| SCHEMBL731177 | 0.75 | MPO (0.46) | KDM4EALDH1A1MAPTGAAMPO | |
| SCHEMBL2255842 | 0.74 | SMN1; SMN2 (0.46) | ALDH1A1TDP1KMT2AMEN1LMNA | |
| SCHEMBL12126259 | 0.74 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL1233517 | 0.74 | BAZ2B (0.54) | KDM4EMAPTGAAMPOKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |