Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702111 | 0.86 | KMT2A (0.44) | KMT2ARAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2521960 | 0.81 | KMT2A (0.48) | KMT2ARAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1458129 | 0.80 | ALDH1A1 (0.50) | KMT2ARAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL15897191 | 0.79 | KMT2A (0.49) | KMT2ARAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL16177307 | 0.79 | SMN1; SMN2 (0.51) | KMT2AALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7451066 | 0.79 | LMNA (0.46) | KMT2ARAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25607515 | 0.79 | KMT2A (0.46) | KMT2ARAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8509672 | 0.78 | LMNA (0.38) | KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL23122103 | 0.77 | ALDH1A1 (0.45) | KMT2ARAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1458264 | 0.77 | CYP2C9 (0.47) | KMT2ARAB9AALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |