Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.59 |
| ▸ | DRD4 | P21917 | 4/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703014 | 0.86 | ADRA1A (0.65) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL7699931 | 0.84 | HTR1A (0.59) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL7536688 | 0.80 | HTR1A (0.72) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL7699944 | 0.80 | ADRA1A (0.63) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL6933222 | 0.78 | HTR1A (0.78) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL6933223 | 0.78 | HTR1A (0.75) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8002128 | 0.77 | HTR1A (0.75) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL6930467 | 0.75 | HTR1A (0.73) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL6931653 | 0.75 | HTR1A (0.73) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8013493 | 0.75 | HTR1A (0.76) | HTR1AADRA1ADRD4ADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344458-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2002-02-05 | — | — | US | claimed |
| EP-1140882-A1 | PIPERAZINE ETHYLAMIDE DERIVATIVES WITH 5-HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035892-A1 | PIPERAZINE ETHYLAMIDE DERIVATIVES WITH 5-HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | claimed |
| US-6344458-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2002-02-05 | — | — | US | disclosed |