Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843747 | 0.90 | MAPK1 (0.53) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL6846139 | 0.71 | MAPK1 (1.00) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL6203512 | 0.70 | TBXA2R (0.40) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL8328864 | 0.70 | ALDH1A1 (0.47) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL7476806 | 0.69 | ALDH1A1 (0.46) | MAPK1HTTGAAMAPTLMNA | |
| SCHEMBL3764481 | 0.69 | MAPK1 (0.70) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL7780381 | 0.69 | NPSR1 (0.70) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL11850324 | 0.69 | MAPK1 (0.70) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL7476808 | 0.69 | ALDH1A1 (0.46) | MAPK1HTTGAAMAPTLMNA | |
| SCHEMBL7787599 | 0.68 | MAPK1 (0.68) | MAPK1HTTNPSR1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002008211-A2 | BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS | G.D. SEARLE, LLC. (US) | 2002-01-31 | — | — | WO | disclosed |