Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | RGS12 | O14924 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Erythro-Hydrobupropion SCHEMBL1227545 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL1226880 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL30252298 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL3320024 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL3320155 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL1229064 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL30252231 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL29465706 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL1226819 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 | |
| Erythro-Hydrobupropion SCHEMBL3320146 | 0.79 | SLC6A4 (0.65) | SLC6A4CHRM2ADRA1AADRA2CCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919841-B2 | Monoamine reuptake inhibitors | RESEARCH TRIANGLE INSTITUTE (US) | 2021-02-16 | — | — | US | disclosed |
| US-20180215701-A1 | MONOAMINE REUPTAKE INHIBITORS | RES TRIANGLE INST (US) | 2018-08-02 | — | — | US | disclosed |
| US-9562001-B2 | Monoamine reuptake inhibitors | RESEARCH TRIANGLE INSTITUTE (US) | 2017-02-07 | — | — | US | disclosed |
| US-20120071560-A1 | MONOAMINE REUPTAKE INHIBITORS | RESEARCH TRIANGLE INSTITUTE | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071560-A1 | MONOAMINE REUPTAKE INHIBITORS | SLC6A2, SLC6A4, SLC6A3 | SLC6A4 2/4885CHRM2 518/4885ADRA1A 70/4885 |
| US-10919841-B2 | Monoamine reuptake inhibitors | SLC6A2, SLC6A4, SLC6A3 | SLC6A4 2/4885CHRM2 518/4885ADRA1A 70/4885 |
| US-20180215701-A1 | MONOAMINE REUPTAKE INHIBITORS | SLC6A2, SLC6A4, SLC6A3 | SLC6A4 2/4885CHRM2 518/4885ADRA1A 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.