Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.67 |
| ▸ | MTOR | P42345 | 11/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769676 | 0.86 | PIK3CA (0.66) | PIK3CAMTORFLT3 | |
| SCHEMBL380433 | 0.80 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL770120 | 0.70 | PSEN1 (0.39) | PIK3CAMTOR | |
| SCHEMBL409076 | 0.66 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL770195 | 0.65 | LPL (0.40) | PIK3CA | |
| SCHEMBL16588375 | 0.63 | FLT3 (0.74) | FLT3GABRG2GABRB3GABRA3 | |
| SCHEMBL3476586 | 0.63 | PIK3CA (0.74) | PIK3CAMTORFLT3 | |
| SCHEMBL380333 | 0.61 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL12276604 | 0.61 | PIK3CD (0.41) | PIK3CAMTOR | |
| SCHEMBL926027 | 0.61 | PSEN1 (0.52) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729074-B2 | Inhibitors of PI3 kinase | AMGEN INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729074-B2 | Inhibitors of PI3 kinase | AMGEN INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20120071474-A1 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071474-A1 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071474-A1 | INHIBITORS OF PI3 KINASE | PIK3CA, PIK3CD, PIK3CG | PIK3CA 1/4885MTOR 23/4885FLT3 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.