Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CYP2A13 | Q16696 | 4/20 | 0.40 |
| ▸ | PRCP | P42785 | 6/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699153 | 1.00 | OPRM1 (0.41) | OPRM1CYP2A13PRCPRECQLGAA | |
| SCHEMBL8509848 | 0.82 | CYP2A13 (0.40) | CYP2A13GAADRD4DRD3TMEM97 | |
| SCHEMBL7702406 | 0.79 | OPRM1 (0.41) | OPRM1CYP2A13PRCPRECQLGAA | |
| SCHEMBL7702411 | 0.79 | OPRM1 (0.41) | OPRM1CYP2A13PRCPRECQLGAA | |
| SCHEMBL7702359 | 0.77 | OPRM1 (0.41) | OPRM1CYP2A13PRCPRECQLGAA | |
| SCHEMBL7704232 | 0.77 | PRCP (0.41) | OPRM1CYP2A13PRCPRECQLGAA | |
| SCHEMBL7704233 | 0.77 | PRCP (0.41) | OPRM1CYP2A13PRCPRECQLGAA | |
| SCHEMBL7702361 | 0.77 | OPRM1 (0.41) | OPRM1CYP2A13PRCPRECQLGAA | |
| SCHEMBL7697817 | 0.75 | CYP2A13 (0.34) | CYP2A13PRCPGAADRD4DRD3 | |
| SCHEMBL7703162 | 0.74 | PRCP (0.57) | OPRM1PRCPRECQLGAAGID4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |