Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 6/20 | 0.54 |
| ▸ | NOS3 | P29474 | 7/20 | 0.40 |
| ▸ | NOS1 | P29475 | 7/20 | 0.40 |
| ▸ | NOS2 | P35228 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252917 | 0.97 | HTR7 (0.59) | HTR7HTR1DHTR6NOS3NOS1 | |
| SCHEMBL7252913 | 0.97 | HTR7 (0.59) | HTR7HTR1DHTR6NOS3NOS1 | |
| SCHEMBL7252947 | 0.87 | HTR7 (0.53) | HTR7HTR1DHTR6NOS3NOS1 | |
| SCHEMBL7253245 | 0.78 | HTR6 (0.60) | HTR7HTR1DHTR6NOS3NOS1 | |
| SCHEMBL7253243 | 0.78 | HTR6 (0.60) | HTR7HTR1DHTR6NOS3NOS1 | |
| SCHEMBL7252886 | 0.77 | HTR7 (0.42) | HTR7HTR1DHTR6DRD2DRD3 | |
| SCHEMBL7253030 | 0.75 | HTR6 (0.59) | HTR1DHTR6 | |
| SCHEMBL7253409 | 0.75 | HTR6 (0.59) | HTR1DHTR6 | |
| SCHEMBL7253026 | 0.75 | HTR6 (0.59) | HTR1DHTR6 | |
| SCHEMBL30641113 | 0.75 | HTR6 (0.92) | HTR6ADRA2ACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380242-B1 | FOR DIAGNOSIS AND THERAPY OF CENTRAL NERVOUS SYSTEM CONDITIONS | NPS ALLELIX CORP. (CA) | 2002-04-30 | — | — | US | disclosed |