⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL887688 | 0.79 | LMNA (0.53) | — | |
| SCHEMBL11600199 | 0.79 | LMNA (0.53) | — | |
| SCHEMBL7755706 | 0.79 | — | — | |
| SCHEMBL1585176 | 0.79 | — | — | |
| SCHEMBL10354597 | 0.77 | — | — | |
| SCHEMBL10354453 | 0.77 | — | — | |
| SCHEMBL738259 | 0.75 | LMNA (0.48) | — | |
| SCHEMBL7707587 | 0.75 | — | — | |
| SCHEMBL1131957 | 0.75 | — | — | |
| SCHEMBL28679245 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111635375-A | Synthetic method of thiazoie | 昆山亚香香料股份有限公司 | 2020-09-08 | — | — | CN | claimed |
| CN-115819370-A | Synthetic method of 4-methyl-5- (beta-hydroxyethyl) -thiazole | 福建菲恩新材料科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-113105410-B | Preparation method of 4-methyl-5- (2-acetoxyethyl) thiazole | 山东吉田香料股份有限公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-113214227-A | Heterocyclic compound and application thereof | 上海青玄生物科技有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-113105410-A | Preparation method of 4-methyl-5- (2-acetoxyethyl) thiazole | 山东吉田香料股份有限公司 | 2021-07-13 | — | — | CN | disclosed |
| CN-111635375-A | Synthetic method of thiazoie | 昆山亚香香料股份有限公司 | 2020-09-08 | — | — | CN | disclosed |
| CN-111635375-A | Synthetic method of thiazoie | 昆山亚香香料股份有限公司 | 2020-09-08 | — | — | CN | disclosed |
| EP-2439202-B1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | SALVAT LAB SA (ES) | 2016-04-20 | — | — | EP | disclosed |
| US-8822452-B2 | Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1 | LABORATORIOS SALVAT, S.A. (ES) | 2014-09-02 | — | — | US | disclosed |
| US-20130303522-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | LABORATORIOS SALVAT, S.A. (ES) | 2013-11-14 | — | — | US | disclosed |
| US-20120071466-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | LABORATORIOS SALVAT, S.A. (ES) | 2012-03-22 | — | — | US | disclosed |
| US-8063240-B2 | Prostaglandin E1 and E2 analogs for the treatment of various medical conditions | CAYMAN CHEMICAL COMPANY, INCORPORATED (US) | 2011-11-22 | — | — | US | disclosed |
| EP-2220057-A2 | PROSTAGLANDIN E1 AND E2 ANALOGS FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS | Cayman Chemical Company (US) | 2010-08-25 | — | — | EP | disclosed |
| US-20090221654-A1 | PROSTAGLANDIN E1 AND E2 ANALOGS FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS | CAYMAN CHEMICAL COMPANY (US) | 2009-09-03 | — | — | US | disclosed |
| WO-2009065070-A2 | PROSTAGLANDIN E1 AND E2 ANALOGS FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS | CAYMAN CHEMICAL COMPANY (US) | 2009-05-22 | — | — | WO | disclosed |
| US-6200976-B1 | FOR TREATING THROMBOSIS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-13 | — | — | US | disclosed |
| US-6114532-A | ANTICOAGULANT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-05 | — | — | US | disclosed |
| US-4244887-A | Substituted ω-pentanorprostaglandins | PFIZER INC. (US) | 1981-01-13 | — | — | US | disclosed |
| US-4087604-A | Substituted ω-pentanorprostaglandins | PFIZER INC. (US) | 1978-05-02 | — | — | US | disclosed |
| US-4024179-A | Substituted ω-pentanorprostaglandins | PFIZER INC. (US) | 1977-05-17 | — | — | US | disclosed |