Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 6/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | HCK | P08631 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | MUSK | O15146 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691837 | 0.80 | RAF1 (0.50) | MAPK14MAPK12MAPK13MAPK11RAF1 | |
| SCHEMBL7700456 | 0.79 | MAPK14 (0.52) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL7839549 | 0.79 | MAPK14 (0.43) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL7841607 | 0.78 | MAPK14 (0.61) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL7845936 | 0.78 | MAPK14 (0.44) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL7696091 | 0.75 | MAPK14 (0.45) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL6243453 | 0.74 | MAPK14 (0.67) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL7840096 | 0.74 | MAPK14 (0.38) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL7854708 | 0.72 | MAPK14 (0.46) | TNFMAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL6162657 | 0.69 | MAPK14 (0.56) | TNFMAPK14MAPK12MAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002539206-A | — | — | 2002-11-19 | — | — | JP | claimed |
| EP-1163236-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-19 | — | — | EP | claimed |
| WO-2000055152-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | claimed |
| EP-1163236-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055152-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |