Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.44 |
| ▸ | HCK | P08631 | 7/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164164 | 0.85 | MAPK14 (0.58) | MAPK14MAPK12HCKTNFGAA | |
| SCHEMBL7841607 | 0.79 | MAPK14 (0.61) | MAPK14MAPK12HCKTNFMAPK13 | |
| SCHEMBL5619419 | 0.79 | MAPK14 (0.52) | MAPK14MAPK12HCKTNFKDM4E | |
| SCHEMBL6162921 | 0.79 | MAPK14 (0.56) | MAPK14MAPK12HCKTNFMAPK13 | |
| SCHEMBL6164402 | 0.78 | RAF1 (0.54) | MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL6165244 | 0.78 | MAPK14 (0.50) | MAPK14MAPK12HCKTNFGAA | |
| SCHEMBL6161599 | 0.78 | MAPK14 (0.58) | MAPK14MAPK12HCKTNFGAA | |
| SCHEMBL7699562 | 0.78 | TNF (0.38) | MAPK14MAPK12HCKTNFKDM4E | |
| SCHEMBL6163708 | 0.77 | GAA (0.46) | MAPK14MAPK12HCKTNFGAA | |
| SCHEMBL5619545 | 0.77 | ALDH1A1 (0.46) | MAPK14MAPK12HCKTNFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055152-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |