Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 16/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.44 |
| ▸ | RAF1 | P04049 | 3/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.37 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.36 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.36 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.36 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.36 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.36 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.36 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.36 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699663 | 0.77 | MAPK14 (0.63) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7699660 | 0.77 | MAPK14 (0.63) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7560872 | 0.73 | MAPK14 (0.72) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7560881 | 0.73 | MAPK14 (0.72) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL6171143 | 0.67 | MAPK14 (0.84) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL6171137 | 0.67 | MAPK14 (0.84) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7672894 | 0.67 | MAPK14 (0.62) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5819635 | 0.67 | MAPK13 (0.62) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7698138 | 0.65 | MAPK14 (0.71) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL17938001 | 0.65 | MAPK14 (1.00) | MAPK14MAPK11MAPK13MAPK12MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131314-A4 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-05-02 | — | — | EP | disclosed |
| EP-1131314-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031065-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2000-06-02 | — | — | WO | disclosed |