Succinic Acid

Succinic Acid

SCHEMBL7700352

CN[C@@H]1CCc2[nH]c3ccc(NC=O)cc3c2C1.O=C(O)CCC(=O)O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR1B known ✓ P28222 3/20 0.68
DRD2 known ✓ P14416 1/20 0.68
DRD4 known ✓ P21917 1/20 0.68
HTR1D known ✓ P28221 1/20 0.59
HTR1F known ✓ P30939 1/20 0.43
HTR1A P08908 2/20 0.68
HTR1E P28566 1/20 0.68
HTR7 P34969 1/20 0.68
OPRM1 P35372 1/20 0.68
TMEM97 Q5BJF2 1/20 0.68
KMT2A Q03164 3/20 0.44
MEN1 O00255 2/20 0.42
KDM4E B2RXH2 1/20 0.41
HPGD P15428 1/20 0.41
CASP6 P55212 1/20 0.41
BAZ2B Q9UIF8 1/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL7024837 1.00 HTR1B (0.68) HTR1BHTR1ADRD2DRD4HTR1E
Succinic Acid SCHEMBL16318529 0.99 HTR1B (0.69) HTR1BHTR1ADRD2DRD4HTR1E
Succinic Acid SCHEMBL7025602 0.99 HTR1B (0.69) HTR1BHTR1ADRD2DRD4HTR1E
Oxalic Acid SCHEMBL7540895 0.93 HTR1B (0.62) HTR1BHTR1ADRD2DRD4HTR1E
SCHEMBL980209 0.92 HTR1B (0.61) HTR1BHTR1ADRD2DRD4HTR1E
SCHEMBL7031093 0.92 HTR1B (0.61) HTR1BHTR1ADRD2DRD4HTR1E
SCHEMBL2301469 0.92 HTR1B (0.61) HTR1BHTR1ADRD2DRD4HTR1E
Bromide SCHEMBL7027435 0.91 HTR1B (0.60) HTR1BHTR1ADRD2DRD4HTR1E
Hydrochloric Acid SCHEMBL3466984 0.91 HTR1B (0.60) HTR1BHTR1ADRD2DRD4HTR1E
Succinic Acid SCHEMBL7031956 0.90 HTR1A (0.55) HTR1BHTR1ADRD2DRD4HTR1E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070051-B1 PROCESS FOR THE PRODUCTION OF R-(+)-6- CARBOXAMIDO- 3-N- METHYLAMINO- 1,2,3,4- TETRAHYDROCARBAZOLE VERNALIS DEV LTD (GB) 2015-06-03 EP disclosed
WO-2014202717-A1 PROCESS FOR THE PREPARATION OF FROVATRIPTAN AND ITS ENANTIOMER DUKE CHEM, S.A. (ES) 2014-12-24 WO disclosed
US-6359146-B1 RESOLUTION OF ENANTIOMORPH MIXTURE VERNALIS LIMITED (GB) 2002-03-19 US disclosed
EP-1070051-A1 PROCESS FOR THE PRODUCTION OF R-(+)-6- CARBOXAMIDO- 3-N- METHYLAMINO- 1,2,3,4- TETRAHYDROCARBAZOLE Vernalis Limited (GB) 2001-01-24 EP disclosed
WO-1999054302-A1 PROCESS FOR THE PRODUCTION OF R-(+)-6- CARBOXAMIDO- 3-N- METHYLAMINO- 1,2,3,4- TETRAHYDROCARBAZOLE VERNALIS LIMITED (GB) 1999-10-28 WO disclosed