Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140578 | 0.88 | ALDH1A1 (0.47) | ALDH1A1MAPTTDP1L3MBTL1KMT2A | |
| SCHEMBL7702830 | 0.84 | NPC1 (0.45) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL7700536 | 0.79 | GRM5 (0.36) | ALDH1A1MAPTTDP1L3MBTL1KMT2A | |
| SCHEMBL7145867 | 0.77 | WDR5 (0.44) | ALDH1A1MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL7145991 | 0.76 | ALDH1A1 (0.44) | ALDH1A1MAPTTDP1L3MBTL1KMT2A | |
| SCHEMBL1025211 | 0.76 | MAPT (0.52) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL1025212 | 0.76 | MAPT (0.52) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL7147535 | 0.76 | GRM5 (0.40) | ALDH1A1MAPTTDP1L3MBTL1LMNA | |
| SCHEMBL6610351 | 0.76 | MAPT (0.42) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL7139831 | 0.75 | GRM5 (0.39) | ALDH1A1MAPTTDP1L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |