Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.49 |
| ▸ | MELK | Q14680 | 2/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.49 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996897 | 0.88 | CHEK1 (0.65) | CHEK1KDR | |
| SCHEMBL7093261 | 0.88 | CHEK1 (0.56) | CHEK1KDRRETMARK3RPS6KA3 | |
| SCHEMBL7701720 | 0.86 | CHEK1 (0.54) | CHEK1KDR | |
| SCHEMBL7095976 | 0.85 | CHEK1 (0.55) | CHEK1KDRCDK2 | |
| SCHEMBL7095965 | 0.82 | CHEK1 (0.65) | CHEK1KDRRETMARK3RPS6KA3 | |
| SCHEMBL7162844 | 0.82 | CHEK1 (0.63) | CHEK1KDRRETMARK3RPS6KA3 | |
| SCHEMBL7814577 | 0.82 | CHEK1 (0.57) | CHEK1KDRCDK2CDK1 | |
| SCHEMBL7704058 | 0.81 | CHRM3 (0.54) | CHEK1 | |
| SCHEMBL7094673 | 0.80 | CD274 (0.59) | CHEK1KDR | |
| SCHEMBL7093375 | 0.80 | CHEK1 (0.50) | CHEK1KDRCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |