Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698769 | 0.86 | KDR (0.58) | CHEK1 | |
| SCHEMBL7701855 | 0.83 | NAMPT (0.64) | NPC1CHEK1 | |
| SCHEMBL7701559 | 0.81 | NAMPT (0.52) | KMT2AMEN1CHEK1 | |
| SCHEMBL7702362 | 0.80 | KDR (0.52) | KMT2AMEN1RAB9AKDM4ECHEK1 | |
| SCHEMBL7701122 | 0.79 | CHEK1 (0.48) | CHEK1 | |
| SCHEMBL7701963 | 0.79 | CHEK1 (0.57) | CHEK1 | |
| SCHEMBL7705692 | 0.79 | CHEK1 (0.62) | KMT2ARAB9ANPC1CHEK1 | |
| SCHEMBL11863990 | 0.78 | KDR (0.63) | KMT2AMEN1KDM4EHIF1ACHEK1 | |
| SCHEMBL7831082 | 0.78 | KDR (0.48) | RAB9AHIF1ACHEK1 | |
| SCHEMBL7701166 | 0.76 | CHEK1 (0.53) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |