Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698769 | 0.86 | KDR (0.58) | CHEK1KDRKITCDK1CDK2 | |
| SCHEMBL7701855 | 0.86 | NAMPT (0.64) | CHEK1KDRNPC1CDK1CDK2 | |
| SCHEMBL7701559 | 0.83 | NAMPT (0.52) | CHEK1KDRL3MBTL1KMT2ACDK1 | |
| SCHEMBL7701963 | 0.83 | CHEK1 (0.57) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7702362 | 0.82 | KDR (0.52) | CHEK1KDRKITPDGFRARAB9A | |
| SCHEMBL7701122 | 0.80 | CHEK1 (0.48) | CHEK1KDRKITCDK1CDK2 | |
| SCHEMBL7701166 | 0.80 | CHEK1 (0.53) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7705309 | 0.79 | KDR (0.69) | CHEK1KDRNPC1CDK1CDK2 | |
| SCHEMBL7702113 | 0.79 | CHEK1 (0.49) | CHEK1KDRKITPDGFRANPC1 | |
| SCHEMBL7701135 | 0.79 | KMT2A (0.53) | CHEK1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |