Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 2/20 | 0.42 |
| ▸ | EEF2 | P13639 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11612693 | 0.98 | EEF2K (0.44) | EEF2KEEF2MEN1PLK4JAK2 | |
| SCHEMBL9522704 | 0.86 | ESR1 (0.41) | MEN1KMT2AALDH1A1RAB9AHTT | |
| SCHEMBL11610261 | 0.79 | RAB9A (0.41) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL9523550 | 0.77 | — | — | |
| SCHEMBL2495415 | 0.77 | TP53 (0.45) | EEF2KEEF2MEN1PLK4JAK2 | |
| SCHEMBL8778695 | 0.76 | ALDH1A1 (0.47) | EEF2KEEF2MEN1PLK4JAK2 | |
| SCHEMBL10767578 | 0.76 | ALDH1A1 (0.47) | EEF2KEEF2MEN1PLK4JAK2 | |
| SCHEMBL12096492 | 0.76 | ALDH1A1 (0.47) | EEF2KEEF2MEN1PLK4JAK2 | |
| SCHEMBL10764271 | 0.76 | ALDH1A1 (0.47) | EEF2KEEF2MEN1PLK4JAK2 | |
| SCHEMBL11613395 | 0.76 | ALDH1A1 (0.47) | EEF2KEEF2MEN1PLK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002020487-A1 | SUBSTITUTED 1-ARYL-PYRIDIN-2-(THI)ONES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-14 | — | — | WO | disclosed |